ABSTRACT
The auditory brainstem response (ABR) is a test widely used to assess the integrity of the brain stem. Although it is considered to be an auditory-evoked potential that is influenced by the physical characteristics of the stimulus, such as rate, polarity and type of stimulus, it may also be influenced by the change in several parameters. The use of anesthetics may adversely influence the value of the ABR wave latency. One of the anesthetics used for e ABR assessment, especially in animal research, is the ketamine/xylazine combination. Our objective was to determine the influence of the ketamine/xylazine anesthetic on the ABR latency values in adult gerbils. The ABRs of 12 adult gerbils injected with the anesthetic were collected on three consecutive days, or a total of six collections, namely: pre-collection and A, B, C, D, and E collections. Before each collection the gerbil was injected with a dose of ketamine (100 mg/kg)/xylazine (4 mg/kg). For the capture of the ABR, 2000 click stimuli were used with rarefaction polarity and 13 stimuli per second, 80 dBnHL intensity and in-ear phones. A statistically significant difference was observed in the latency of the V wave in the ABR of gerbils in the C and D collections compared to the pre-, A and E collections, and no difference was observed between the pre-, A, B, and E collections. We conclude that the use of ketamine/xylazine increases the latency of the V wave of the ABR after several doses injected into adult gerbils; thus clinicians should consider the use of this substance in the assessment of ABR.
Subject(s)
Animals , Male , Anesthetics/pharmacology , Evoked Potentials, Auditory, Brain Stem/drug effects , Ketamine/pharmacology , Xylazine/pharmacology , Anesthetics/administration & dosage , Auditory Threshold/drug effects , Gerbillinae , Ketamine/administration & dosage , Reaction Time , Xylazine/administration & dosageSubject(s)
Humans , Benzodiazepinones , Duodenal Ulcer , Clinical Trials as Topic , Double-Blind Method , PlacebosABSTRACT
Os autores apresentam um caso de coriangioma complicado por hidropisia fetal e polidramnio transitorios destacando a importancia do diagnostico ultra-sonografic
Subject(s)
Pregnancy , Adult , Humans , Female , Hemangioma , Placenta , UltrasonographyABSTRACT
Apresentam os autores uma paciente portadora de melorreostose em osso iliaco direito com achados radiologico, cintilografico e histopatologico, assim como comentam dados de literatura
Subject(s)
Middle Aged , Humans , Female , Ilium , MelorheostosisABSTRACT
E descrito um caso de vesicula biliar com dois septos parciais drenando atraves de um cistico longo, de curso espiralado cruzando o hepatico comum e a ele se unindo na papila de Vater. Estas anomalias foram observadas por meio da colecistografia oral apos uma refeicao gordurosa
Subject(s)
Adult , Humans , Female , Cholecystography , Congenital Abnormalities , GallbladderABSTRACT
O autor apresenta um caso de rabdomiossarcoma paratesticular na infancia. Salienta a importancia do diagnostico precoce e do tratamento cirurgico erradicativo para um melhor prognostico, ja que estes tumores sao radiorresistentes e pouco se conhece a respeito da sua resposta a quimioterapia dado a raridade do mesmo
Subject(s)
Child , Humans , Male , Testicular Neoplasms , RhabdomyosarcomaABSTRACT
E estudado o valor da cimetidina na profilaxia da hemorragia digestiva em casos de hepatite fulminante. Em 8 pacientes, dos quais o antagosnista dos receptores H2 foi administrado, a frequencia de hemorragia foi de 25%, significativamente menor que na sua experiencia anterior (52%) e aqueda registrada na literatura (54%)